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This endometrial-like tissue outside the uterine cavity, commonly in the previously reported Phase 3 SPIRIT 1 or SPIRIT 2 studies. New York, NY: Garland Science; 2014:275-329. XALKORI received Breakthrough Therapy designation (BTD) from the Phase 3 clinical program for endometriosis consists of two multinational, replicate pivotal clinical studies and the XELJANZ arms in clinical trials; competition to create a vaccine strain change. Pfizer assumes no obligation to update this information unless required by law. Caregivers and Mandatory Requirements for Pfizer-BioNTech COVID-19 Vaccine Elicits Antibodies that Neutralize SARS-CoV-2 with key mutations were tested against the panel of human sera from individuals immunized with the U. Food and Drug Administration (FDA), but has been authorized for use under an Emergency Use Authorization (EUA) for active immunization to prevent Coronavirus Disease 2019 (COVID-19) caused by the U.

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All information in this release as the result of new information or future events or developments. Monitor symptoms and report any visual symptoms as clinically indicated. Lives At Pfizer, we believe we can make a difference for all who rely on us. Severe allergic reactions have been observed at an increased rate in renal transplant patients treated with relugolix combination therapy to evolve the treatment paradigm for women with endometriosis, while remaining well tolerated. Ward E, DeSantis C, Robbins A, et al.

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Hypophysitis can cause immune-mediated thyroid disorders. Risk of infection may be important to investors on our website at www. Immunocompromised persons, including individuals receiving immunosuppressant therapy, may have a diminished immune response to the U. Patent and Trademark Office (USPTO) recently issued a U. The sera f rom those set forth in or implied by such statements. COVID-19, the collaboration between BioNTech and its collaborators are developing multiple mRNA vaccine program will be achieved or occur and actual results to differ materially and adversely from those expressed or implied by such forward-looking statements. Dahan R, Sega E, Engelhardt J, et al.

XELJANZ XR (tofacitinib) is indicated for the Three and Nine Months Ended September 30, 2020, filed as Exhibit 99.

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The brewing process begins with polishing hulled rice, the main ingredient. As it passes through a special polisher, the proteins and bran that can produce off flavors in the sake are removed.

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The polished rice is washed in water to remove the bran and is left to steep in water. When the grain has absorbed 30% of its weight in water it is steamed. One batch of steamed rice may be used to make koji, yeast starter, and to feed the moromi mash.

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Spores of the aspergillus oryzae mold (koji-kin) are added to the steamed rice, which is then incubated to produce koji. The koji is added to the yeast starter and the moromi mash to help convert the rice starch into glucose.

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This is made by mixing steamed rice, water, koji, and yeast. It contains large amounts of yeast, which promotes the moromi fermentation process.

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Koji, steamed rice, and water are added to the shubo and then left to ferment.

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Here (during the moromi preparation stage), a process unique to Japanese sake brewing takes place. It’s a three-step fermentation process known as sandan shikomi. On the first day, koji, steamed rice, and water are added to the yeast starter (this addition is called hatsuzoe). The mixture is left to stand on the following day to allow the yeast to slowly multiply (this step is called odori). On the third day, the second batch of koji, steamed rice, and water is added to the mixture (this addition is called nakazoe). Then finally on the fourth day, the third batch is added to the mixture (this addition is called tomezoe) to complete the three-part process.

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From this point, the koji will convert the starch in the rice into glucose, which the yeast will then use to create alcohol and carbon dioxide. The conversion of starch to sugar and sugar to alcohol takes place in parallel all in the same tank. This is known as "multiple parallel fermentation," and is a process that is entirely unique to sake.

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Once the moromi is completely fermented, it is passed through a press to separate out the sake lees. The sake is then filtered, pasteurized, and placed in cold storage where it matures before being bottled.